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Hou et al (2005) examined the autonomic results of modafinil in humans. They observed that modafinil has an effect on the locus coeruleus, which mediates pupil diameter and arousal, but it doesn't have an effect on other autonomic features, that are controlled by noreadrenergic Regulate facilities (A1 – A5) Positioned beyond the locus coeruleus.A

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